![]() Of these, 70 completed (37 in the active and 33 in the placebo groups). ResultsĪ total of 95 participants were randomised, of which 81 commenced the trial. Fasting blood samples were collected pre- and post-intervention which were used to measure the primary outcome of change in B vitamin biomarker levels. Each B vitamin-fortified drink (200 ml) contained 200 µg folic acid, 10 µg vitamin B12, 10 mg vitamin B6 and 5 mg riboflavin, while the placebo was an identical, isocaloric formulation without added B vitamins. Recruited participants meeting the inclusion criteria were randomised (by sex and study centre) to receive daily for 16 weeks either B vitamin-fortified or placebo drinks as developed by Smartfish, Norway. taking medications known to interfere with B vitamin metabolism, supplements containing B vitamins, consuming > 4 portions of B vitamin-fortified foods per week or diagnosed with gastrointestinal, liver or pulmonary disease). Participants aged > 50 years were recruited following screening for exclusion criteria (i.e. MethodsĪ double-blinded randomised controlled trial was performed in parallel at University College Dublin and Ulster University. The objectives of the OptiAge food intervention study were to develop and investigate the effectiveness of a B vitamin-fortified drink in improving B vitamin biomarkers in older Irish adults with a primary outcome of change in the B vitamin biomarker status. Older adults are reported to have sub-optimal B vitamin status targeted food-based solutions may help to address this.
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